Sources told that the drone fired four missiles on the house near Miramshah bazaar in Sirai Darpakhel area, targeting the Haqqani residential compound and a car.
The head commander Haji Shahrifullah of Haqqani, a militant network, is said to be safe, whereas 18 people were killed and two others injured in the attack. Intelligence sources confirmed the death toll.
US officials consider the Haqqani network to be one of the most dangerous militant factions fighting American troops in Afghanistan.
The leadership of the Haqqani network pledges allegiance to Afghan Taliban chief Mullah Omar but operates fairly independently.
The drone attack was the biggest launched this year and the second since Nawaz Sharif took office as prime minister following his victory in the May 11 elections.
Nawaz has called for an immediate end to US drone strikes on the grounds they breach of Pakistan’s sovereignty.
Meanwhile, the Foreign Office condemned the latest US drone strike that took place in North Waziristan late on Tuesday.
At least 18 people were killed and two others injured in the drone attack which targeted a house in North Waziristan’s Miramshah town late on Wednesday.
Hours after the strike, the Foreign Office issued a statement saying drone strikes were a violation of Pakistan’s sovereignty and territorial integrity, adding that Pakistan has repeatedly emphasized the importance of bringing an immediate end to these.
The government “has consistently maintained that drone strikes are counter-productive, entail loss of innocent civilian lives and have human rights and humanitarian implications”, the statement said.
It further said that the attacks had a negative impact on the “mutual desire” of both countries to forge “a cordial and cooperative relationship and to ensure peace and stability in the region”.