Two hosts, Areej Zayat and Reine Neilah, broadcast the “From Syria With Love” show on the Talaqi channel from 9:00 pm local time (1900 GMT) on Tuesday to 7:00 pm on Friday.
The channel, based in central Damascus, said it hoped the performance would be recognised by Guinness as an official world record.
The current record stands at 62 hours held by a channel in Nepal.
The broadcast, posted on YouTube, features telephone call-ins, music and dancing.
“We wanted to send a message through this programme that this country, beset by all kinds of suffering, can send a message of love to the world and that life goes on for the Syrian people,” channel director Maher al-Khaouli told AFP.
The channel is aimed at young people and was launched in October 2012, more than a year after the start of a revolt against President Bashar al-Assad that has morphed into a bloody civil war that has killed close to 200,000 people.